PRS Web Service - submit request

Welcome to the PRS Web Service

Instructions

This web service allows users to query findings from an analysis of PRS (polygenic risk scores) selected from the PGS Catalog for 15 available traits in the SG10K_Health dataset. Users can select a PRS and one or more traits in the request form on the right, as well as the genetic sex and ancestry of their choice. These inputs will be used to stratify the SG10K population for analysis of the PRS.

The generated report will contain:
1) PRS variant QC breakdown in the population,
2) PRS distribution in SG10K_Health (by ancestry and research cohorts),
3) Meta-analysis of the PRS and selected trait(s) across ancestry and research cohorts in the population.
The generated report will be sent as a HTML file to the email address provided. A sample report may be viewed at here.

Request

A PRS web report will be sent to your email address. Please verify the following user information.

Please wait while we are retrieving your information...

Please enter your parameters before submit the request.

PRS Score *
Traits / Phenotypes *















Genetic Sex *
Genetic Ancestry *
Analysis Title
Reset Submit
Please enter the parameters
Info dialog
The polygenic scores are selected from the PGS Catalog based on the 15 available traits in SG10K_Health, as of April 7, 2021. Please click on it to select it.
Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s)
(Ontology) 		Number of Variants
PGS000020dGRS1000PGP000010
Läll K et al. Genet Med (2016) 		Type 2 diabetestype II diabetes mellitus7,502
PGS000034GRS_BMIPGP000021
Song M et al. Diabetes (2017) 		Adult Body Mass Indexbody mass index97
PGS000036gePS_T2DPGP000023
Mahajan A et al. Nat Genet (2018) 		Type 2 diabetestype II diabetes mellitus171,249
PGS000060GRS_HDLPGP000045
Johnson L et al. PLoS One (2015) 		high-density lipoprotein (HDL) cholesterolhigh density lipoprotein cholesterol measurement46
PGS000061GRS_LDLPGP000045
Johnson L et al. PLoS One (2015) 		low-density lipoprotein (LDL) cholesterollow density lipoprotein cholesterol measurement37
PGS000062GRS_TCPGP000045
Johnson L et al. PLoS One (2015) 		total cholesteroltotal cholesterol measurement52
PGS000063GRS_TGPGP000045
Johnson L et al. PLoS One (2015) 		triglyceridestriglyceride measurement32
PGS000064GLGC2017_HDLPGP000046
Kuchenbaecker K et al. Nat Commun (2019) 		High density lipoprotein (HDL) cholesterolhigh density lipoprotein cholesterol measurement120
PGS000065GLGC2017_LDLPGP000046
Kuchenbaecker K et al. Nat Commun (2019) 		Low density lipoprotein (HDL) cholesterollow density lipoprotein cholesterol measurement103
PGS000066GLGC2017_TGPGP000046
Kuchenbaecker K et al. Nat Commun (2019) 		Triglycerides (TG)triglyceride measurement101
PGS000115LDL-C_20PGP000053
Trinder M et al. JAMA Cardiol (2020) 		low density lipoprotein cholesterollow density lipoprotein cholesterol measurement223
PGS000125Qi_T2D_2017PGP000062
Qi Q et al. Diabetes (2017) 		Type 2 Diabetestype II diabetes mellitus80
PGS000127GS-E-EURPGP000064
Wheeler E et al. PLoS Med (2017) 		Hemoglobin A1cHbA1c measurement21
PGS000128GS-E-AFRPGP000064
Wheeler E et al. PLoS Med (2017) 		Hemoglobin A1cHbA1c measurement22
PGS000129GS-E-EASPGP000064
Wheeler E et al. PLoS Med (2017) 		Hemoglobin A1cHbA1c measurement17
PGS000130GS-G-EURPGP000064
Wheeler E et al. PLoS Med (2017) 		Hemoglobin A1cHbA1c measurement19
PGS000131GS-G-AFRPGP000064
Wheeler E et al. PLoS Med (2017) 		Hemoglobin A1cHbA1c measurement19
PGS000132GS-G-EASPGP000064
Wheeler E et al. PLoS Med (2017) 		Hemoglobin A1cHbA1c measurement19
PGS000192GS9PGP000079
Kathiresan S et al. N Engl J Med (2008) 		Cholesterolhigh density lipoprotein cholesterol measurement
low density lipoprotein cholesterol measurement		9
PGS000297GRS3290_HeightPGP000092
Xie T et al. Circ Genom Precis Med (2020) 		Heightbody height3,290
PGS000298GRS941_BMIPGP000092
Xie T et al. Circ Genom Precis Med (2020) 		Body mass indexbody mass index941
PGS000299GRS462_WHRadjBMIPGP000092
Xie T et al. Circ Genom Precis Med (2020) 		Waist-to-hip ratio (body mass index adjusted)BMI-adjusted waist-hip ratio462
PGS000301GRS970_SBPPGP000092
Xie T et al. Circ Genom Precis Med (2020) 		Systolic blood pressuresystolic blood pressure970
PGS000302GRS962_DBPPGP000092
Xie T et al. Circ Genom Precis Med (2020) 		Diastolic blood pressurediastolic blood pressure962
PGS000304GRS43_HbA1cPGP000092
Xie T et al. Circ Genom Precis Med (2020) 		HbA1cHbA1c measurement43
PGS000305GRS31_FGPGP000092
Xie T et al. Circ Genom Precis Med (2020) 		Fasting glucosefasting blood glucose measurement31
PGS000306GRS19_FGadjBMIPGP000092
Xie T et al. Circ Genom Precis Med (2020) 		Fasting glucose (body mass index adjusted)BMI-adjusted fasting blood glucose measurement19
PGS000309GRS247_HDLPGP000092
Xie T et al. Circ Genom Precis Med (2020) 		High-density lipoproteinhigh density lipoprotein cholesterol measurement247
PGS000310GRS194_LDLPGP000092
Xie T et al. Circ Genom Precis Med (2020) 		Low-density lipoproteinlow density lipoprotein cholesterol measurement194
PGS000311GRS234_TCPGP000092
Xie T et al. Circ Genom Precis Med (2020) 		Total cholesteroltotal cholesterol measurement234
PGS000312GRS190_TGPGP000092
Xie T et al. Circ Genom Precis Med (2020) 		Triglyceridestriglyceride measurement190
PGS000330PRS_T2DPGP000100
Mars N et al. Nat Med (2020) 		Type 2 diabetestype II diabetes mellitus6,437,380
PGS000340LDL-CpspPGP000107
Trinder M et al. Circ Genom Precis Med (2020) 		Low-density lipoprotein cholesterol levelslow density lipoprotein cholesterol measurement28
PGS000658PRS-TCPGP000121
Tam CHT et al. Genome Med (2021)		Total cholesteroltotal cholesterol measurement229
PGS000659PRS-TGPGP000121
Tam CHT et al. Genome Med (2021)		Triglyceridestriglyceride measurement142
PGS000660PRS-HDLPGP000121
Tam CHT et al. Genome Med (2021)		HDL cholesterolhigh density lipoprotein cholesterol measurement549
PGS000661PRS-LDLPGP000121
Tam CHT et al. Genome Med (2021)		LDL choldesterollow density lipoprotein cholesterol measurement84
PGS000677snpnet.Cholesterol_adjstatinsPGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)		Cholesterol [mmol/L] (statin adjusted)total cholesterol measurement17,204
PGS000684snpnet.GlucosePGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)		Glucose [mmol/L]glucose measurement3,313
PGS000685snpnet.Glycated_haemoglobin_HbA1cPGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)		HbA1c [mmol/mol]HbA1c measurement14,658
PGS000686snpnet.HDL_cholesterolPGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)		HDL cholesterol [mmol/L]high density lipoprotein cholesterol measurement25,069
PGS000688snpnet.LDL_direct_adjstatinsPGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)		LDL cholesterol [mmol/L] (statin adjusted)low density lipoprotein cholesterol measurement16,184
PGS000699snpnet.TriglyceridesPGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)		Triglycerides [mmol/L]triglyceride measurement16,003
PGS000706HC215PGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)		Hypertensionhypertension186,726
PGS000712T2D_HbA1c_39PGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)		T2D (cases vs HbA1c filtered controls)type II diabetes mellitus183,695
PGS000713T2DPGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)		T2Dtype II diabetes mellitus183,830
PGS000729T2D_PGSPGP000137
Ritchie SC et al. bioRxiv (2019)|Pre		Type 2 diabetestype II diabetes mellitus2,017,388
PGS000758LASSO_HeightPGP000163
Lu T et al. J Clin Endocrinol Metab (2021)		Adult standing heightbody height33,938